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Purvalanol B
CAS No. 212844-54-7
Purvalanol B( NG-95 )
Catalog No. M13388 CAS No. 212844-54-7
A potent, cell-permeable, selective inhibitor of CDK with IC50s of 6, 6, 9, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5-p35 respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 60 | In Stock |
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| 10MG | 78 | In Stock |
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| 25MG | 136 | In Stock |
|
| 50MG | 203 | In Stock |
|
| 100MG | 305 | In Stock |
|
| 200MG | 461 | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePurvalanol B
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, cell-permeable, selective inhibitor of CDK with IC50s of 6, 6, 9, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5-p35 respectively.
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DescriptionA potent, cell-permeable, selective inhibitor of CDK with IC50s of 6, 6, 9, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5-p35 respectively; no inhibition for cdk4/cyclin D1 (>10 uM); has no effect on Erk1, PKC, Raf, CK1, CK2.
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In VitroPurvalanol B binds to P. falciparum casein kinase 1 (CK1) from blood stage cell lysates and inhibits the growth a chloroquine-resistant strain of P. falciparum (FCR-3) with an IC50 of 7.07 μM.
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In Vivo——
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SynonymsNG-95
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number212844-54-7
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Formula Weight432.9039
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Molecular FormulaC20H25ClN6O3
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 40 mg/mL
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SMILESCC(C)N1C2=NC(N[C@H](C(C)C)CO)=NC(NC3=CC(Cl)=C(C(O)=O)C=C3)=C2N=C1
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Chemical NameBenzoic acid, 2-chloro-4-[[2-[[(1R)-1-(hydroxymethyl)-2-methylpropyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gray NS, et al. Science. 1998 Jul 24;281(5376):533-8.
2. Chang YT, et al. Chem Biol. 1999 Jun;6(6):361-75.
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